What is Premanin?
PREMARIN is a hormone therapy that contains a combination of estrogens. It can help you manage the symptoms of menopause, including hot flashes, night sweats, and vaginal dryness, as well as reduce your chances of developing osteoporosis (thin, weak bones).

PREMARIN is for women without a uterus (hysterectomy) who have moderate to severe menopausal symptoms—hot flashes, night sweats, and vaginal dryness.

When your only menopausal symptom is vaginal dryness, your health care professional may recommend you use a topical vaginal product, such as PREMARIN Vaginal Cream.

It is best to take PREMARIN at the lowest possible effective dose for the shortest period of time. For this reason, PREMARIN comes in five dosage strengths so that you and your physician can determine which dose is best for you. Studies have shown that PREMARIN was effective in relieving the hot flashes, night sweats, and vaginal dryness related to menopause, and can also help to prevent osteoporosis.

For women who have not had a hysterectomy and are experiencing moderate to severe menopausal symptoms, PREMARIN can also be used in combination with a progestin tablet, or your health care professional may recommend PREMPRO, another member of the PREMARIN Family, which contains both estrogen and progestin.

Is PREMARIN right for me?
If your menopausal symptoms are moderate to severe, PREMARIN may be an appropriate treatment option for you. Every woman is different, but as many as half of the women in menopause will experience some moderate to severe symptoms during the first few years of menopause. You and your health care professional can decide which approach to managing menopausal symptoms may be right for you.

A good first step toward understanding your symptoms is to complete the Menopausal Symptoms Assessor. It will only take a few minutes and, when you`re finished, you`ll have a symptom profile to print out and bring with you when you talk to your doctor or health care professional.

If your only symptoms are vaginal, such as dryness, burning, and itching, which can make intimacy uncomfortable or painful, your health care professional may recommend a topical therapy. He or she may prescribe PREMARIN Vaginal Cream. It is equally important to review your family history with your health care professional prior to beginning therapy with PREMARIN. If there is a family history of heart disease, breast cancer, stroke, blood clots, or osteoporosis, be sure to tell your health care professional.

Relieving the symptoms of menopause
Because every woman experiences menopause differently, it is important to assess your symptoms and to discuss these, as well as the level of relief you can expect with PREMARIN, with your health care professional.

In general, you can expect relief from your moderate to severe menopausal symptoms to begin quickly with PREMARIN. You may begin to feel relief from hot flashes in 1 to 3 weeks.

Hot flashes and night sweats are likely to become less frequent and intense. This trend in improvement should continue over time.

Relief from vaginal symptoms—dryness, burning, and itching—may take 3 weeks. If you need relief only from vaginal dryness, ask your health care professional about topical therapies. He or she may prescribe PREMARIN Vaginal Cream. PREMARIN has been proven to relieve menopausal symptoms even at the lowest dose.

Preventing osteoporosis
Estrogen plays a critical role in maintaining bone strength in women. The drop in estrogen levels that accompanies menopause results in increased bone loss. Here`s some helpful information about this problem.

Up to 20 percent of a woman`s lifetime bone loss may occur in the years immediately following menopause. Although you cannot feel it happening, this bone loss can lead to postmenopausal osteoporosis. Osteoporosis is a disease in which the amount of bone is decreased and the structural integrity of the bone is impaired. Under a microscope, normal bone looks like a dense sponge. Osteoporosis increases the size of the holes in the sponge-like structure, and makes the material that surrounds the holes finer, more delicate, and more easily broken.

Postmenopausal women are especially susceptible to fractures of the hip, wrists, and spine. PREMARIN can help reduce your chances of developing osteoporosis because it has been shown to increase bone mineral density at the hip and spine and can help prevent postmenopausal osteoporosis.

- In the first few years after menopause, you may begin to rapidly lose bone mineral density.
- PREMARIN has been proven to increase bone mineral density at the hip and the spine and help prevent postmenopausal osteoporosis.
- In addition to the prevention of osteoporosis, PREMARIN has been proven to alleviate moderate to severe symptoms of menopause, such as hot flashes, night sweats, and vaginal symptoms.

If you do not have menopausal symptoms, such as hot flashes and night sweats, non-estrogen treatments should be carefully considered before taking PREMARIN solely for the prevention of postmenopausal osteoporosis.

The lowest effective dose of PREMARIN should be used. That is why PREMARIN offers five dosage strengths, so your health care professional can choose the one that is right for you.

Because no two women are the same, PREMARIN offers a range of doses to meet the needs of different women, including two low-dose options, PREMARIN 0.3 mg and PREMARIN 0.45 mg.

You and your health care professional should determine the appropriate dose for you. You should see your doctor regularly while taking therapy to discuss the effects and to review your treatment plan.

How long will I be on therapy?
PREMARIN does not need to be taken for the rest of your life. The U.S. Food and Drug Administration (FDA) recommends that women who choose hormone therapy to manage menopausal symptoms should use the lowest effective dose for the shortest time, consistent with treatment goals and risks.

What if I miss a dose?
You`ll achieve your best results with PREMARIN if you remember to take it every day, as prescribed by your health care professional. If you`re taking PREMARIN and you miss a dose, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double your doses.

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